{"id":10004,"date":"2022-07-08T04:30:00","date_gmt":"2022-07-08T04:30:00","guid":{"rendered":"https:\/\/www.prnasia.com\/story\/archive\/3810836_AE10836_0"},"modified":"2022-07-08T04:30:00","modified_gmt":"2022-07-08T04:30:00","slug":"hkumed-and-cityu-scientists-discover-non-invasive-stimulation-of-the-eye-for-depression-and-dementia","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=10004","title":{"rendered":"HKUMed and CityU Scientists Discover Non-invasive Stimulation of the Eye for Depression and Dementia"},"content":{"rendered":"<p><span class=\"xn-location\">HONG KONG<\/span>, <span class=\"xn-chron\">July 8, 2022<\/span> \/PRNewswire\/ &#8212; A joint research team from Li Ka Shing Faculty of Medicine, The <span class=\"xn-org\">University of Hong Kong<\/span> (HKUMed) and City <span class=\"xn-org\">University of Hong Kong<\/span> (CityU) has discovered that electrical stimulation of the eye surface can alleviate depression-like symptoms and improve cognitive function in animal models.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\" readability=\"15\">\n<p> <a href=\"https:\/\/mma.prnasia.com\/media2\/1855634\/L_R__Prof_Chan_Ying_Shing_Dr_Leanne_Chan_Lai_Hang_PhD_Student.html\" target=\"_blank\" rel=\"nofollow noopener\"> <img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/1855634\/L_R__Prof_Chan_Ying_Shing_Dr_Leanne_Chan_Lai_Hang_PhD_Student.jpg?p=medium600\" title=\"(L-R) Prof. Chan Ying-Shing, Dr Leanne Chan Lai-Hang, PhD Student Yu Wing-Shan, and Dr Lim Lee Wei, the principal investigator and also a former Singapore Lee Kuan Yew Research Fellow,&nbsp;discovered non-invasive stimulation of the eye for depression and dementia. (Source of photo: HKUMed Neuromodulation Laboratory)\" alt=\"(L-R) Prof. Chan Ying-Shing, Dr Leanne Chan Lai-Hang, PhD Student Yu Wing-Shan, and Dr Lim Lee Wei, the principal investigator and also a former Singapore Lee Kuan Yew Research Fellow,&nbsp;discovered non-invasive stimulation of the eye for depression and dementia. (Source of photo: HKUMed Neuromodulation Laboratory)\"> <\/a> <br \/><span>(L-R) Prof. Chan Ying-Shing, Dr Leanne Chan Lai-Hang, PhD Student Yu Wing-Shan, and Dr Lim Lee Wei, the principal investigator and also a former Singapore Lee Kuan Yew Research Fellow,&nbsp;discovered non-invasive stimulation of the eye for depression and dementia. (Source of photo: HKUMed Neuromodulation Laboratory)<\/span><\/p>\n<\/p><\/div>\n<p>Major depression is the most common and severe psychiatric disorder across the world. Recently, the World Health Organization reported that the COVID-19 pandemic has triggered a massive increase in the number of people with anxiety and depression.&nbsp;Although treatments are available for depression, about a quarter of patients do not respond adequately to these treatments.<\/p>\n<p>Assistant Professor Dr <span class=\"xn-person\">Lim Lee Wei<\/span>, the principal investigator and also a former Singapore Lee Kuan Yew Research Fellow, reported in 2015 that deep brain stimulation of the prefrontal cortex in the brains of animals could improve memory function and relieve depressive symptoms. These therapeutic effects were attributed to the growth of brain cells in the hippocampus, a brain region known to be involved in learning and memory function. However, this technique also known as deep brain stimulation is invasive and requires surgery to implant electrodes in the brain, which may cause side effects such as infections and post-operative complications.<\/p>\n<p>A team of <span class=\"xn-location\">Hong Kong<\/span> researchers headed by Dr <span class=\"xn-person\">Lim Lee Wei<\/span>, Dr <span class=\"xn-person\">Leanne Chan Lai-Hang<\/span>, and Prof <span class=\"xn-person\">Chan Ying-Shing<\/span> have been looking for alternative ways to treat neuropsychiatric diseases. They discovered that non-invasive stimulation of the corneal surface in the eye that activates brain pathways, resulted in remarkable antidepressant-like effects and also reduced stress hormones in an animal model of depression. This technique called transcorneal electrical stimulation also induced the expression of genes involved in the development and growth of brain cells in the hippocampus.<\/p>\n<p>In related experiments, <span class=\"xn-person\">Yu Wing-Shan<\/span> and other research members investigated whether this approach could also be used to treat Alzheimer&#8217;s disease, a common type of dementia with no definitive cure. They found that this non-invasive stimulation in mice drastically improved memory performance and reduced beta-amyloid deposits in the hippocampus, which is one of the hallmarks of Alzheimer&#8217;s disease.<\/p>\n<p>Associate Professor Dr <span class=\"xn-person\">Leanne Chan<\/span>, the lead researcher at CityU and an expert on the electrical stimulation of visual and non-visual brain targets, described this research, &#8216;Transcorneal electrical stimulation is a non-invasive method initially developed to treat eye diseases, and it would be a major scientific breakthrough if it could be applied to treat neuropsychiatric diseases.&#8217;<\/p>\n<p>&#8216;These research findings pave the way for new therapeutic opportunities to develop novel treatment for patients suffering from treatment-resistant depression and dementia, nevertheless, clinical trials must be conducted to validate the efficacy and safety,&#8217; remarked Professor <span class=\"xn-person\">Chan Ying-Shing<\/span> of the HKUMed and Editor-in-Chief of IBRO Neuroscience Reports. The application of this non-invasive stimulation of the eye brings new hope for those with depression and dementia.<\/p>\n<p>These significant findings were recently published in <i><a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(22)00096-1\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">Brain Stimulation<\/a><\/i>&nbsp;and <i><a href=\"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.14850\" target=\"_blank\" rel=\"nofollow noopener\">Annals of the New York Academy of Sciences<\/a><\/i>. <span class=\"xn-person\">Yu Wing Shan<\/span>, who was the main researcher of these studies, and a recipient of the prestigious Hong Kong PhD Fellowship, awarded by the Hong Kong Research Grants Council at the HKUMed Neuromodulation Laboratory (<a href=\"http:\/\/www.drlimlab.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.drlimlab.com<\/a>), in collaboration with CityU at the Neural Interface Research Laboratory (<a href=\"http:\/\/www.ee.cityu.edu.hk\/~lhchan\" target=\"_blank\" rel=\"nofollow noopener\">www.ee.cityu.edu.hk\/~lhchan<\/a>).&nbsp;<\/p>\n<p><b>References<\/b><\/p>\n<p>WS Yu, ACK Tse, L Guan, JLY Chiu, SZK Tan, S Khairuddin, SK Agadagba, ACY Lo, ML Fung, YS Chan, LLH Chan, LW Lim. (2022) Antidepressant-like behaviors by transcorneal electrical stimulation in rat models. <span class=\"xn-person\">Brain Stim<\/span>. 15(3):843-856.&nbsp;<\/p>\n<p>WS Yu, L Aquili, KH Wong, ACY Lo, LLH Chan, YS Chan, LW Lim. (2022) Transcorneal electrical stimulation enhances cognitive functions in aged and 5xFAD mouse models. Ann. NY Acad. Sci. DOI: 10.1111\/nyas.14850.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HONG KONG, July 8, 2022 \/PRNewswire\/ &#8212; A joint research team from Li Ka Shing Faculty of Medicine, The University of Hong Kong (HKUMed) and City University of Hong Kong (CityU) has discovered that electrical stimulation of the eye surface can alleviate depression-like symptoms and improve cognitive function in animal models. (L-R) Prof. Chan Ying-Shing, [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":10005,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-10004","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-business-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HKUMed and CityU Scientists Discover Non-invasive Stimulation of the Eye for Depression and Dementia - My Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/transmediavictoria.net.au\/?p=10004\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HKUMed and CityU Scientists Discover Non-invasive Stimulation of the Eye for Depression and Dementia - My Blog\" \/>\n<meta property=\"og:description\" content=\"HONG KONG, July 8, 2022 \/PRNewswire\/ &#8212; A joint research team from Li Ka Shing Faculty of Medicine, The University of Hong Kong (HKUMed) and City University of Hong Kong (CityU) has discovered that electrical stimulation of the eye surface can alleviate depression-like symptoms and improve cognitive function in animal models. 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