{"id":12937,"date":"2022-10-24T15:30:00","date_gmt":"2022-10-24T15:30:00","guid":{"rendered":"https:\/\/www.prnasia.com\/story\/archive\/3912004_AE12004_0"},"modified":"2022-10-24T15:30:00","modified_gmt":"2022-10-24T15:30:00","slug":"t-cells-treated-by-turn-biotechnologies-show-increased-cancer-killing-effectiveness","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=12937","title":{"rendered":"T-cells treated by Turn Biotechnologies show increased cancer-killing effectiveness"},"content":{"rendered":"<div id=\"dvContent\" readability=\"102.03169486973\">\n<ul type=\"disc\">\n<li><i>Preclinical data showing how ERA\u2122, eTurna\u2122&nbsp;technologies turbocharge T-cell therapies presented at New Frontiers of RNA Nanotherapeutics meeting today <\/i><\/li>\n<li><i>ERA\u2122 boosts CAR T-cell efficacy by overcoming T-cell exhaustion that inhibits cancer cures<\/i><\/li>\n<li><i>eTurna\u2122&nbsp;delivery platform delivers more healthy, functional T-cells than electroporation, without the safety risks of viral vectors<\/i><\/li>\n<li><i>Use of both technologies has the potential to lower cost of T-cell therapies, expand patient access <\/i><\/li>\n<\/ul>\n<p><span class=\"xn-location\">MOUNTAIN VIEW, Calif.<\/span>, <span class=\"xn-chron\">Oct. 24, 2022<\/span> \/PRNewswire\/ &#8212; Turn Biotechnologies, a cell rejuvenation company developing novel mRNA medicines to cure untreatable, age-related conditions, today presents interim pre-clinical data that demonstrates treating T cells with its proprietary technologies can significantly increase their ability to kill cancer.<\/p>\n<div id=\"prni_dvprnejpg4b6fleft\" dir=\"ltr\"> <a href=\"https:\/\/mma.prnasia.com\/media2\/1927460\/GettyImages_1227506537.jpg?p=medium600\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" id=\"prnejpg4b6fleft\" title=\"Turn Biotechnologies interim data show that treating T cells with ERA technology makes them more effective cancer killers.\" src=\"https:\/\/mma.prnasia.com\/media2\/1927460\/GettyImages_1227506537.jpg?p=medium600\" alt=\"Turn Biotechnologies interim data show that treating T cells with ERA technology makes them more effective cancer killers.\" align=\"middle\"><\/a> <br \/><span>Turn Biotechnologies interim data show that treating T cells with ERA technology makes them more effective cancer killers.<\/span> <\/div>\n<p>The data show that using Turn Bio&#8217;s Epigenetic Reprogramming of Aging (ERA\u2122) technology and its eTurna\u2122&nbsp;delivery platform in the manufacture of T cells can produce and deliver more effective therapies more efficiently. The findings promise to help reduce the cost of T-cell therapies and make them more accessible to cancer patients.<\/p>\n<p>&#8220;Our data show that using ERA technology&nbsp;and our eTurna delivery platform can overcome the fundamental problem of T-cell exhaustion&nbsp;and aging&nbsp;that limit the efficacy and long-term effectiveness of CAR-T therapies,&#8221; said <span class=\"xn-person\">Vittorio Sebastiano<\/span>, company co-founder and head of research. &#8220;ERA provides the opportunity for enhanced dose management and optimization with the ability to personalize dosing to maximize efficiency without compromising patient safety.<\/p>\n<p>&#8220;We found eTurna preserves T-cell health and functionality better than electroporation, facilitating greater cell viability and production during CAR T manufacturing,&#8221; he said. &#8220;It also provides superior safety compared to viral gene delivery, thus mitigating many manufacturing, biological and regulatory challenges.&#8221;<\/p>\n<p>Sebastiano&#8217;s presentation, &#8220;First Look Data: Epigenetic Reprogramming of Aging (ERA) \u2013 A New Paradigm in Cell Rejuvenation,&#8221; takes place at New Frontiers of RNA Nanotherapeutics, at <span class=\"xn-chron\">10 a.m. CST<\/span> at Houston Methodist Research Institute.<\/p>\n<p>Turn Bio&#8217;s technologies were applied concurrently with the CAR T-cell manufacturing process, which demonstrates that T-cell immunotherapy products can be enhanced without additional time or facilities beyond those already needed for manufacturing.<\/p>\n<p>The company&#8217;s process can transfect immune cells with rates as high as industry-standard electroporation, but with no cytotoxicity. The eTurna Platform\u2122 was used to precisely control timing, duration and activation of the ERA factor cocktail while preserving cellular identity.<\/p>\n<p> <b>ABOUT TURN BIOTECHNOLOGIES <\/b> <\/p>\n<p>Turn Bio is a pre-clinical-stage company focused on repairing tissue at the cellular level and developing transformative drug delivery systems. The company&#8217;s proprietary mRNA platform technology, ERA\u2122, restores optimal gene expression by combatting the effects of aging in the epigenome. This restores cells&#8217; ability to prevent or treat disease and heal or regenerate tissue. Its eTurna\u2122&nbsp;Delivery Platform uses unique formulations to precisely deliver cargo to specific organs, tissues and cell types.<\/p>\n<p>The company is completing pre-clinical research on tailored therapies targeting indications in dermatology and immunology, and developing therapies for ophthalmology, osteo-arthritis and the muscular system. For more information, see <a href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=3686069-1&amp;h=2676754810&amp;u=http%3A%2F%2Fwww.turn.bio%2F&amp;a=www.turn.bio\" target=\"_blank\" rel=\"nofollow noopener\">www.turn.bio<\/a>.<\/p>\n<p><b>FOR MORE INFORMATION, CONTACT:<\/b><\/p>\n<p><span class=\"xn-person\">Jim Martinez<\/span>, rightstorygroup<br \/><a href=\"mailto:jim@rightstorygroup.com\" target=\"_blank\" rel=\"nofollow noopener\">jim@rightstorygroup.com<\/a>&nbsp;or (312) 543-9026<\/p>\n<\/p><\/div>\n<p>Source: Turn Biotechnologies, Inc.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Preclinical data showing how ERA\u2122, eTurna\u2122&nbsp;technologies turbocharge T-cell therapies presented at New Frontiers of RNA Nanotherapeutics meeting today ERA\u2122 boosts CAR T-cell efficacy by overcoming T-cell exhaustion that inhibits cancer cures eTurna\u2122&nbsp;delivery platform delivers more healthy, functional T-cells than electroporation, without the safety risks of viral vectors Use of both technologies has the potential to [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":12938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-12937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-business-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - 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