{"id":18985,"date":"2023-05-29T05:21:00","date_gmt":"2023-05-29T05:21:00","guid":{"rendered":"https:\/\/www.prnasia.com\/story\/archive\/4113057_CN13057_0"},"modified":"2023-05-29T05:21:00","modified_gmt":"2023-05-29T05:21:00","slug":"collaborators-at-the-keio-and-osaka-universities-present-key-non-clinical-data-with-stable-functional-induced-regulatory-t-cells-s-f-itregs-in-autoimmune-disease-models","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=18985","title":{"rendered":"Collaborators at the Keio and Osaka Universities Present Key Non-Clinical Data with Stable\/Functional-Induced Regulatory T Cells (S\/F-iTregs) in Autoimmune Disease Models"},"content":{"rendered":"
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OSAKA, Japan<\/span><\/span>, May 29, 2023<\/span><\/span> \/PRNewswire\/ — RegCell collaborators from Keio University<\/span> and Osaka<\/span> University presented key data at ISID 2023 Tokyo Satellite Meeting. Their presentation demonstrated that in a murine pemphigus model, S\/F-iTregs significantly decreased clinical scores, circulating anti-Dsg3 IgG titers, and other autoimmune markers related to Pemphigus. Collaborators also reported that S\/F-iTregs generated from samples obtained from patients with Pemphigus also showed potent inhibition of autologous T cell proliferation in vitro.<\/p>\n

Pemphigus is a serious and sometimes fatal autoimmune skin disease. RegCell’s proprietary platform allows for creating induced antigen-specific regulatory T-cells (Tregs) that are stable in vivo and maintain a high degree of functionality (S\/F-iTregs). RegCell was cofounded by Professor Shimon Sakaguchi<\/span> from Osaka<\/span> university and Kyoto<\/span> university, who is credited with the original discovery of Tregs.<\/p>\n

Tregs play a central role in managing immune self-tolerance and depleted or dysfunctional Tregs are characteristic of many autoimmune disorders. “There has been interest in using Tregs as a treatment for autoimmune disorders for many years.  However, to date, these efforts have been limited by lack of antigen-specificity and persistence. The ability to create stable\/functional Treg cells that are antigen-specific has until now been elusive. We believe that RegCell’s proprietary platform can accomplish this goal by inducing Tregs from antigen-specific effector T-cells that appear to maintain their functionality, and we look forward to advancing our S\/F-iTreg platform into clinical development”, said Professor Sakaguchi.<\/p>\n

About RegCell<\/b><\/p>\n

RegCell is a preclinical-stage biotechnology company located in Japan<\/span> with investment from leading Japanese institutional investors including The University of Tokyo<\/span> Edge Capital Partners.  RegCell is developing S\/F-iTregs as a potential treatment for patients with autoimmune disorders and to prevent transplant rejection. <\/p>\n

For more information about RegCell please visit https:\/\/regcell.jp\/en\/<\/a><\/p>\n

Contact: Daisuke Ishikawa<\/span>, Ph.D. (hpregcell@regcell.jp<\/a>)<\/p>\n<\/p><\/div>\n

Source: RegCell Co., Ltd.<\/p>\n","protected":false},"excerpt":{"rendered":"

OSAKA, Japan, May 29, 2023 \/PRNewswire\/ — RegCell collaborators from Keio University and Osaka University presented key data at ISID 2023 Tokyo Satellite Meeting. Their presentation demonstrated that in a murine pemphigus model, S\/F-iTregs significantly decreased clinical scores, circulating anti-Dsg3 IgG titers, and other autoimmune markers related to Pemphigus. Collaborators also reported that S\/F-iTregs generated […]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-18985","post","type-post","status-publish","format-standard","hentry","category-business-news"],"yoast_head":"\nCollaborators at the Keio and Osaka Universities Present Key Non-Clinical Data with Stable\/Functional-Induced Regulatory T Cells (S\/F-iTregs) in Autoimmune Disease Models - My Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/transmediavictoria.net.au\/?p=18985\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Collaborators at the Keio and Osaka Universities Present Key Non-Clinical Data with Stable\/Functional-Induced Regulatory T Cells (S\/F-iTregs) in Autoimmune Disease Models - My Blog\" \/>\n<meta property=\"og:description\" content=\"OSAKA, Japan, May 29, 2023 \/PRNewswire\/ — RegCell collaborators from Keio University and Osaka University presented key data at ISID 2023 Tokyo Satellite Meeting. 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