{"id":28162,"date":"2024-07-22T11:48:00","date_gmt":"2024-07-22T11:48:00","guid":{"rendered":"https:\/\/www.prnasia.com\/story\/archive\/4466289_AE66289_0"},"modified":"2024-07-22T11:48:00","modified_gmt":"2024-07-22T11:48:00","slug":"nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=28162","title":{"rendered":"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency"},"content":{"rendered":"

SHANGHAI<\/span>, July 22, 2024<\/span> \/PRNewswire\/ — The molecular design strategy and experimental results of Bright Gene’s dual GLP-1\/GIP receptor agonist, BGM0504, have been published online in Scientific Reports, a sub-journal of Nature, on July 19, 2024<\/span>. Bright Gene (Stock Code: 688166.SH) is an innovative pharmaceutical company emerging on the international stage, is focused on developing best-in-class pharmaceuticals to improve patient health globally.<\/p>\n

The article, titled “Molecular Dynamics Guided Optimization of BGM0504 Enhances Dual Target Agonism for Combating Diabetes and Obesity”, presents the findings of BGM0504’s development.<\/p>\n

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BGM0504, an AI-assisted designed dual GIP and GLP-1 receptor agonist, demonstrates superior efficacy in both in vitro<\/i> and in vivo<\/i> experiments. Using AI-driven computer simulations, Bright Gene has discovered that optimal interaction between the glutamate residues on both GLP-1R and GIPR and the K20 residue of a peptide agonist provide superior activity. This interaction is a key insight not evident in cryo-EM studies. BGM0504 was designed to preserve the free amino group of the K20 residue by shifting the acylation point to position 40 of BGM0504. This design resulted in a 3-fold increase in agonistic effects on GLP-1R and GIPR, with superior therapeutic outcomes in diabetic and obesity mouse models.<\/p>\n

About Bright Gene and BGM0504<\/b><\/p>\n

Bright Gene (Stock Code: 688166.SH) is an innovative pharmaceutical company focused on developing best-in-class pharmaceuticals. The company integrates APIs and formulations, combining generic and innovative drugs to meet global clinical needs. BGM0504 is a dual GIP\/GLP-1 receptor agonist for treating type 2 diabetes, obesity, and NASH, currently in the late stages of Phase II clinical trials.<\/p>\n

Reference<\/b><\/p>\n

Yuan, J., Liu, W., Jiang, X. et al. Molecular dynamics-guided optimization of BGM0504 enhances dual-target agonism for combating diabetes and obesity. Sci Rep 14, 16680 (2024). https:\/\/doi.org\/10.1038\/s41598-024-66998-8<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

SHANGHAI, July 22, 2024 \/PRNewswire\/ — The molecular design strategy and experimental results of Bright Gene’s dual GLP-1\/GIP receptor agonist, BGM0504, have been published online in Scientific Reports, a sub-journal of Nature, on July 19, 2024. Bright Gene (Stock Code: 688166.SH) is an innovative pharmaceutical company emerging on the international stage, is focused on developing […]<\/p>\n","protected":false},"author":8,"featured_media":28163,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-28162","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-business-news"],"yoast_head":"\nNature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency - My Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/transmediavictoria.net.au\/?p=28162\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency - My Blog\" \/>\n<meta property=\"og:description\" content=\"SHANGHAI, July 22, 2024 \/PRNewswire\/ — The molecular design strategy and experimental results of Bright Gene’s dual GLP-1\/GIP receptor agonist, BGM0504, have been published online in Scientific Reports, a sub-journal of Nature, on July 19, 2024. Bright Gene (Stock Code: 688166.SH) is an innovative pharmaceutical company emerging on the international stage, is focused on developing […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/transmediavictoria.net.au\/?p=28162\" \/>\n<meta property=\"og:site_name\" content=\"My Blog\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-22T11:48:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnasia.com\/media2\/2465919\/image_5031720_25221542.jpg?p=medium600\" \/>\n<meta name=\"author\" content=\"admin_tony\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin_tony\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/transmediavictoria.net.au\\\/?p=28162#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/transmediavictoria.net.au\\\/?p=28162\"},\"author\":{\"name\":\"admin_tony\",\"@id\":\"https:\\\/\\\/transmediavictoria.net.au\\\/#\\\/schema\\\/person\\\/5b51d407d652c0aa802bea269ea5d7e7\"},\"headline\":\"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency\",\"datePublished\":\"2024-07-22T11:48:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/transmediavictoria.net.au\\\/?p=28162\"},\"wordCount\":300,\"image\":{\"@id\":\"https:\\\/\\\/transmediavictoria.net.au\\\/?p=28162#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/transmediavictoria.net.au\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/nature-study-reveals-ai-and-molecular-dynamics-designed-bgm0504-exhibits-superior-potency.jpg\",\"articleSection\":[\"Business News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/transmediavictoria.net.au\\\/?p=28162\",\"url\":\"https:\\\/\\\/transmediavictoria.net.au\\\/?p=28162\",\"name\":\"Nature Study Reveals: AI and Molecular Dynamics Designed BGM0504 Exhibits Superior Potency - 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