{"id":29897,"date":"2024-09-20T12:30:00","date_gmt":"2024-09-20T12:30:00","guid":{"rendered":"https:\/\/www.prnasia.com\/story\/archive\/4511631_CN11631_0"},"modified":"2024-09-20T12:30:00","modified_gmt":"2024-09-20T12:30:00","slug":"biosyngen-best-in-class-next-generation-tumor-infiltrating-lymphocyte-til-technology-debuts-on-esmo-2024-annual-meeting","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=29897","title":{"rendered":"Biosyngen Best-in-Class Next-Generation Tumor-Infiltrating Lymphocyte (TIL) Technology Debuts on ESMO 2024 Annual Meeting"},"content":{"rendered":"<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2462064\/Biosyngen_Logo.jpg?p=medium600\" border=\"0\" alt title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"legendSpanClass\"><span class=\"xn-location\">BARCELONA, Spain<\/span><\/span>, <span class=\"legendSpanClass\"><span class=\"xn-chron\">Sept. 20, 2024<\/span><\/span> \/PRNewswire\/ &#8212; The highly anticipated&nbsp;<b>2024 European Society for Medical Oncology (ESMO) Annual Congress has taken place from <span class=\"xn-chron\">September 13 to 17<\/span> in <span class=\"xn-location\">Barcelona, Spain<\/span>.<\/b> As one of the most influential annual gatherings in oncology, this congress brings together leading cancer experts and researchers from around the globe, showcasing the latest advancements in the field and providing high-quality educational and networking opportunities for oncology professionals.<\/p>\n<p>Biosyngen, an innovative biotechnology company specializing in immune cell therapies, has showcased its <b>groundbreaking technology on gene-modified, functionally enhanced tumor-infiltrating lymphocytes (TILs) derived from liver cancer biopsy samples.<\/b><\/p>\n<p>BioSyngen has secured ten clinical trial approvals in <span class=\"xn-location\">China<\/span> and the U.S. for its innovative fourth-generation oncology therapies. Currently, <b>our leading pipeline product, BRG01, is in the pivotal Phase II clinical trial stage for solid tumors. Additionally, the first patients have been enrolled in the Phase I trials for our other groundbreaking therapies, BST02 and <span class=\"xn-money\">BRL03<\/span>, with completion of Phase I trials anticipated later this year.<\/b><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder8834\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2510772\/image_5006429_29051411.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2510772\/image_5006429_29051411.jpg?p=medium600\" title alt><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p><b>Abstract Title<\/b><\/p>\n<p>Pre-clinical Development of Genetically Modified Tumor-infiltrating Lymphocytes using Biopsy Samples from Liver Cancer Patients<\/p>\n<p><b>Abstract No.<\/b><\/p>\n<p>1034P<\/p>\n<p>Tumor-infiltrating lymphocytes (TILs) are heterogeneous lymphocyte populations within the tumor microenvironment that contains T cells capable of recognizing tumor- or virus-associated antigens.<b> In February of this year, the FDA approved the first TIL-based therapy used with IL-2 for advanced metastatic\/recurrent melanoma. <\/b>However, due to the variability in T cell infiltration between hot and cold tumors, differential abundance of antigen-specific T cells with robust immune response functionality, and the dependence of TIL anti-tumor efficacy on concomitant use of high-dose IL-2 combination therapy, the therapeutic applications of non-edited TILs are quite limited outside of melanoma.<\/p>\n<p>To address these challenges, <b>Biosyngen has developed a proprietary platform for expanding TILs from biopsy samples, achieving production of 10<sup>11<\/sup> cells within four weeks.<\/b> Additionally, the company has established a stable gene modification platform that reprograms TIL metabolism, enhances TIL activity and sustained antitumor efficacy by expressing membrane anchor proteins. Anti-tumor efficacy has significantly enhanced (without IL-2 co-injection) and no obvious toxicity observed.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder7062\" readability=\"7\">\n<p><a href=\"https:\/\/mma.prnasia.com\/media2\/2510773\/Figure_1_BSGTIL_antitumor_efficacy.html\" target=\"_blank\" rel=\"nofollow noopener\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2510773\/Figure_1_BSGTIL_antitumor_efficacy.jpg?p=medium600\" title=\"Figure 1 BSGTIL antitumor efficacy\" alt=\"Figure 1 BSGTIL antitumor efficacy\"><\/a><br \/><span>Figure 1 BSGTIL antitumor efficacy<\/span><\/p>\n<\/p><\/div>\n<p>Biosyngen houses best-in-class proprietary TIL platform aiming to expand the clinical applications of TIL technology with following features:<\/p>\n<ol type=\"1\">\n<li><b>Efficient Automated&nbsp;TILs Manufacturing System:<\/b> Pioneering the use of tumor biopsy samples for TIL preparation with the ability to cryopreserve both tumor tissue and final products, overcoming logistical constraints.<\/li>\n<li><b>Effective In Vitro Gene-engineering System:<\/b> Employs viral vector technology for stable gene modification, maintaining high gene expression efficiency in TILs.<\/li>\n<li><b>Enhanced In&nbsp;Vivo Expansion and Persistence: <\/b>Increased proportion of central memory T cells (T<sub>CM<\/sub>) in the final product, leading to prolonged persistence.<\/li>\n<li><b>Powerful&nbsp;Antitumor Efficacy:<\/b> Demonstrates strong tumor-killing effects without the need for concomitant use of IL-2.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>BARCELONA, Spain, Sept. 20, 2024 \/PRNewswire\/ &#8212; The highly anticipated&nbsp;2024 European Society for Medical Oncology (ESMO) Annual Congress has taken place from September 13 to 17 in Barcelona, Spain. As one of the most influential annual gatherings in oncology, this congress brings together leading cancer experts and researchers from around the globe, showcasing the latest [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":29898,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-29897","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-business-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biosyngen Best-in-Class Next-Generation Tumor-Infiltrating Lymphocyte (TIL) Technology Debuts on ESMO 2024 Annual Meeting - My Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/transmediavictoria.net.au\/?p=29897\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biosyngen Best-in-Class Next-Generation Tumor-Infiltrating Lymphocyte (TIL) Technology Debuts on ESMO 2024 Annual Meeting - My Blog\" \/>\n<meta property=\"og:description\" content=\"BARCELONA, Spain, Sept. 20, 2024 \/PRNewswire\/ &#8212; The highly anticipated&nbsp;2024 European Society for Medical Oncology (ESMO) Annual Congress has taken place from September 13 to 17 in Barcelona, Spain. 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