{"id":32697,"date":"2024-12-31T13:50:00","date_gmt":"2024-12-31T13:50:00","guid":{"rendered":"https:\/\/www.prnasia.com\/story\/archive\/4587286_CN87286_0"},"modified":"2024-12-31T13:50:00","modified_gmt":"2024-12-31T13:50:00","slug":"carsgen-announces-the-initiation-of-an-investigator-initiated-trial-for-an-allogeneic-cd19-cd20-car-t-therapy","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=32697","title":{"rendered":"CARsgen Announces the Initiation of an Investigator-Initiated Trial for an Allogeneic CD19\/CD20 CAR-T Therapy"},"content":{"rendered":"\n\n\n
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SHANGHAI<\/span><\/span>, Dec. 31, 2024<\/span><\/span> \/PRNewswire\/ — CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces the initiation of an investigator-initiated trial (IIT) in China<\/span> for KJ-C2219, an allogeneic CAR T-cell therapy, targeting CD19\/CD20. The trial will evaluate KJ-C2219 for the treatment of relapsed\/refractory B-cell non-Hodgkin lymphoma (R\/R B-NHL).<\/p>\n

KJ-C2219 is developed based on CARsgen’s THANK-u Plus platform and is designed for the treatment of hematologic malignancies and autoimmune diseases.<\/p>\n

About THANK-u Plus<\/b><\/p>\n

CARsgen has developed the THANK-u Plus platform as an enhanced version of its proprietary THANK-uCAR\u00ae<\/sup> allogeneic CAR-T technology to address the potential impact of NKG2A expression levels on therapeutic efficacy. THANK-u Plus demonstrates sustained expansion regardless of varying NKG2A expression levels on NK cells and exhibits significantly improved expansion compared to THANK-uCAR\u00ae<\/sup>. Preclinical studies show that THANK-u Plus delivers superior antitumor efficacy in the presence of NK cells compared to THANK-uCAR\u00ae<\/sup>. Allogeneic BCMA or dual-targeting CD19\/CD20 CAR-T cells developed using this platform exhibit robust antitumor activity in the presence of NK cells, indicating that THANK-u Plus has broad potential for developing diverse allogeneic CAR-T therapies.<\/p>\n

About CARsgen Therapeutics Holdings Limited<\/b><\/p>\n

CARsgen is a biopharmaceutical company with operations in China<\/span> and the U.S., focusing on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors. CARsgen has established a comprehensive CAR T-cell research and development platform that covers target discovery, innovative CAR T-cell development, clinical trials, and commercial-scale production. Internally, CARsgen has developed novel technologies and a product pipeline with global rights to address significant challenges faced by existing CAR T-cell therapies. Efforts include improving safety profile, enhancing the efficacy in treating solid tumors, and reducing treatment costs. CARsgen’s mission is to become a global biopharmaceutical leader that provides innovative and differentiated cell therapies for cancer patients worldwide and makes cancer curable.<\/p>\n

Forward-looking Statements<\/b><\/p>\n

All statements in this press release that are not historical fact or that do not relate to present facts or current conditions are forward-looking statements. Such forward-looking statements express the Group’s current views, projections, beliefs and expectations with respect to future events as of the date of this press release. Such forward-looking statements are based on a number of assumptions and factors beyond the Group’s control. As a result, they are subject to significant risks and uncertainties, and actual events or results may differ materially from these forward-looking statements and the forward-looking events discussed in this press release might not occur. Such risks and uncertainties include, but are not limited to, those detailed under the heading “Principal Risks and Uncertainties” in our most recent annual report and interim report and other announcements and reports made available on our corporate website, https:\/\/www.carsgen.com<\/a>. No representation or warranty is given as to the achievement or reasonableness of, and no reliance should be placed on, any projections, targets, estimates or forecasts contained in this press release.<\/p>\n

For more information, please visit https:\/\/www.carsgen.com\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

SHANGHAI, Dec. 31, 2024 \/PRNewswire\/ — CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces the initiation of an investigator-initiated trial (IIT) in China for KJ-C2219, an allogeneic CAR T-cell therapy, targeting CD19\/CD20. The trial will evaluate KJ-C2219 for […]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-32697","post","type-post","status-publish","format-standard","hentry","category-business-news"],"yoast_head":"\nCARsgen Announces the Initiation of an Investigator-Initiated Trial for an Allogeneic CD19\/CD20 CAR-T Therapy - My Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/transmediavictoria.net.au\/?p=32697\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CARsgen Announces the Initiation of an Investigator-Initiated Trial for an Allogeneic CD19\/CD20 CAR-T Therapy - My Blog\" \/>\n<meta property=\"og:description\" content=\"SHANGHAI, Dec. 31, 2024 \/PRNewswire\/ — CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces the initiation of an investigator-initiated trial (IIT) in China for KJ-C2219, an allogeneic CAR T-cell therapy, targeting CD19\/CD20. 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