{"id":35409,"date":"2025-04-08T01:00:00","date_gmt":"2025-04-08T01:00:00","guid":{"rendered":"https:\/\/www.prnasia.com\/story\/archive\/4658833_AE58833_0"},"modified":"2025-04-08T01:00:00","modified_gmt":"2025-04-08T01:00:00","slug":"engine-biosciences-and-experimental-drug-development-centre-partner-to-advance-novel-therapies-to-combat-cancer","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=35409","title":{"rendered":"Engine Biosciences and Experimental Drug Development Centre Partner to Advance Novel Therapies to Combat Cancer"},"content":{"rendered":"<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2658970\/Engine_Logo.jpg?p=medium600\" border=\"0\" alt title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul type=\"disc\">\n<li><i>This&nbsp;<\/i><i>marks the first-ever <\/i><i>collaboration <\/i><i>between<\/i><i>&nbsp;Engine <\/i><i>Biosciences<\/i><i>&nbsp;and <\/i><i>Experimental Drug Development Centre (EDDC), <span class=\"xn-location\">Singapore&#8217;s<\/span> national<\/i><i>&nbsp;platform for drug discovery and development<\/i><i>. <\/i><\/li>\n<li><i>The partnership will<\/i><i>&nbsp;advance <\/i><i>the development of first-in-class precision therapeutics for multiple<\/i><i>&nbsp;cancer <\/i><i>types that are highly prevalent in <span class=\"xn-location\">Singapore<\/span> and globally, including breast, liver, kidney and prostate cancers.<\/i>&nbsp;<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\"><span class=\"xn-location\">SINGAPORE<\/span><\/span>, <span class=\"legendSpanClass\"><span class=\"xn-chron\">April 8, 2025<\/span><\/span> \/PRNewswire\/ &#8212; Engine Biosciences (Engine), a <span class=\"xn-location\">Singapore<\/span>&#8211; and Silicon Valley-based biotechnology company pioneering precision medicine for cancer, announced a new partnership with the Experimental Drug Development Centre (EDDC), <span class=\"xn-location\">Singapore&#8217;s<\/span> national platform for drug discovery and development hosted by the Agency for Science, Technology and Research (A*STAR).&nbsp;<\/p>\n<p>This first-of-its-kind collaboration unites Engine&#8217;s NetMAPPR platform and proprietary oncology intellectual property with EDDC&#8217;s drug discovery and development expertise to create first-in-class precision cancer treatments.<\/p>\n<p>The first project under this partnership focuses on ENB-871, a novel pairing of a drug target and patient selection biomarkers discovered through Engine&#8217;s NetMAPPR platform. This platform combines AI, computation, biology, and chemistry to identify, validate, and prioritise drug targets with strong clinical and commercial potential, driving the development of new therapies that exploit specific vulnerabilities in tumours.<\/p>\n<p>This program shows significant promise for treating tumours with particular&nbsp;genetic mutations that predict sensitivity to the ENB-871 targeted therapy, including breast, liver, kidney and prostate cancers \u2013 diseases afflicting large and growing&nbsp;patient populations in <span class=\"xn-location\">Singapore<\/span> and worldwide. In total, the potential addressable population exceeds 500,000 patients per year.<\/p>\n<p>The teams will collaborate&nbsp;to develop small molecule degraders targeting ENB-871, including demonstration&nbsp;of <i>in vivo<\/i> efficacy. By bringing together Engine&#8217;s proprietary technology and deep translational insights with EDDC&#8217;s strengths in designing and developing therapies, this partnership aims to create targeted cancer treatments tailored to patients&#8217; specific profiles, improving treatment effectiveness and outcomes. Engine and EDDC may also identify additional drug targets and research programs for collaboration during the partnership.<\/p>\n<p>&#8220;We&#8217;re excited by the synergies created by bringing together our two platforms, leveraging first-in-class <span class=\"xn-location\">Singapore<\/span> research and innovation to advance transformative cancer therapies. This marks another key step in Engine&#8217;s mission to develop more effective, targeted and safer drugs for cancer patients.&#8221;&nbsp;said <span class=\"xn-person\">Jeffrey Lu<\/span>, CEO and Co-Founder of Engine Biosciences.<\/p>\n<p>&#8220;The future of drug development lies in precision-driven innovation. Our partnership with Engine enables us to develop therapies tailored to specific patient populations through Engine&#8217;s biomarker-driven patient selection approaches. We are particularly excited to launch our first collaborative project around monovalent small molecule degraders, building on EDDC&#8217;s expanding capabilities in this field. Beyond this, we look forward to strengthening our partnership by advancing more precision therapies that have the potential to transform the lives of cancer patients in need,&#8221; shared <span class=\"xn-person\">Damian O&#8217;Connell<\/span>, CEO of EDDC.<\/p>\n<p><b>About Engine Biosciences<br \/><\/b>Engine Biosciences (Engine) is a venture-backed <span class=\"xn-location\">Singapore<\/span> and Silicon Valley based company discovering and developing impactful precision medicines by deciphering complex biology with integrated computation and experimentation, with particular depth in oncology gained over several years of substantial investment and focus. Having pinpointed many promising drug targets and predictive biomarkers for patients most likely to benefit, Engine is advancing its pipeline of oncology therapeutics towards the clinic internally and with collaborators, and in other disease areas through partnerships. Engine&#8217;s team is motivated by opportunities to address significant unmet needs with more selective and effective precision medicines. For more information, please visit&nbsp;<a href=\"http:\/\/www.enginebio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.enginebio.com<\/a>, and follow Engine on&nbsp;<a href=\"https:\/\/www.linkedin.com\/company\/engine-biosciences\/\" target=\"_blank\" rel=\"nofollow noopener\">LinkedIn<\/a>.<\/p>\n<p><b>About EDDC<br \/><\/b>The Experimental Drug Development Centre (EDDC) is <span class=\"xn-location\">Singapore&#8217;s<\/span> national platform for drug discovery and development, formed from the integration of the Experimental Therapeutics Centre (ETC), Drug, Discovery and Development (D3), and Experimental Biotherapeutics Centre (EBC) in 2019. EDDC aims to develop therapeutics and diagnostics that save and improve the lives of patients in <span class=\"xn-location\">Singapore<\/span>, <span class=\"xn-location\">Asia<\/span> and around the world. Hosted by the Agency for Science, Technology and Research (A*STAR), EDDC works collaboratively with public sector and industry partners to translate the great science arising from <span class=\"xn-location\">Singapore&#8217;s<\/span> biomedical and clinical sciences R&amp;D into innovative healthcare solutions. For more information about EDDC, please visit&nbsp;<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fapc01.safelinks.protection.outlook.com%2F%3Furl%3Dhttp%253A%252F%252Fwww.eddc.sg%252F%26data%3D05%257C01%257Cruyu.wang%2540xtalpi.com%257C356da3081288484b9ab008dbe6643f26%257C9ef30927ff65483cbe8ac6d6c19596f4%257C0%257C0%257C638357090510862482%257CUnknown%257CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%253D%257C3000%257C%257C%257C%26sdata%3Dn8ZYYLuKSmDos%252FGMkNWdZPkxatg2IBLuVcWwz4tJno8%253D%26reserved%3D0&amp;esheet=53873703&amp;newsitemid=20231221788895&amp;lan=en-US&amp;anchor=http%3A%2F%2Fwww.eddc.sg%2F&amp;index=4&amp;md5=d3118b48771cf9de49d96e4de9a55a16\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/www.eddc.sg\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This&nbsp;marks the first-ever collaboration between&nbsp;Engine Biosciences&nbsp;and Experimental Drug Development Centre (EDDC), Singapore&#8217;s national&nbsp;platform for drug discovery and development. The partnership will&nbsp;advance the development of first-in-class precision therapeutics for multiple&nbsp;cancer types that are highly prevalent in Singapore and globally, including breast, liver, kidney and prostate cancers.&nbsp; SINGAPORE, April 8, 2025 \/PRNewswire\/ &#8212; Engine Biosciences (Engine), a [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-35409","post","type-post","status-publish","format-standard","hentry","category-business-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Engine Biosciences and Experimental Drug Development Centre Partner to Advance Novel Therapies to Combat Cancer - My Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/transmediavictoria.net.au\/?p=35409\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Engine Biosciences and Experimental Drug Development Centre Partner to Advance Novel Therapies to Combat Cancer - My Blog\" \/>\n<meta property=\"og:description\" content=\"This&nbsp;marks the first-ever collaboration between&nbsp;Engine Biosciences&nbsp;and Experimental Drug Development Centre (EDDC), Singapore&#8217;s national&nbsp;platform for drug discovery and development. 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