{"id":44781,"date":"2026-06-03T22:01:00","date_gmt":"2026-06-03T22:01:00","guid":{"rendered":"http:\/\/www.prnasia.com\/story\/archive\/4971116_AE71116_0"},"modified":"2026-06-03T22:01:00","modified_gmt":"2026-06-03T22:01:00","slug":"era-congress-semaglutide-linked-to-better-quality-of-life-in-diabetes-and-kidney-disease-flow-trial-shows","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=44781","title":{"rendered":"ERA Congress: Semaglutide linked to better quality of life in diabetes and kidney disease, FLOW trial shows"},"content":{"rendered":"\n<p><span class=\"legendSpanClass\">GLASGOW, Scotland<\/span>, <span class=\"legendSpanClass\">June 4, 2026<\/span> \/PRNewswire\/ &#8212; <b>New<\/b>&nbsp;<b>findings from the landmark FLOW trial, presented at the 63<sup>rd<\/sup> ERA Congress, show that once-weekly semaglutide significantly improved health-related quality of life in adults with type 2 diabetes (T2D) and chronic kidney disease (CKD), equivalent to around eight additional days in full health per year. <\/b><\/p>\n<p>The trial previously demonstrated that semaglutide reduced the risk of major kidney disease events by 24% and all-cause mortality by 20% compared with placebo over a median treatment duration of 3.4 years. This new analysis provides complementary patient-centred evidence, showing that the benefits of semaglutide may extend beyond traditional clinical outcomes to how patients feel and function in everyday life.<\/p>\n<p>For people living with both T2D and CKD, symptoms, treatment burden and reduced physical functioning can substantially affect day-to-day well-being, making quality of life an increasingly important treatment goal.<\/p>\n<p>Among 3,533 randomised participants in the FLOW trial, 1,767 received semaglutide and 1,766 received placebo. Health-related quality of life was assessed using the EQ-5D-5L questionnaire, a patient-reported measure of health status and well-being covering mobility, self-care, usual activities, pain\/discomfort, anxiety\/depression, and overall health perception.<\/p>\n<p>After two years of treatment, health utility scores \u2013 which range from 0 (death) to 1 (perfect health) \u2013 remained stable in the semaglutide group but declined in those receiving placebo. The estimated treatment difference of +0.021 (p=0.0001) corresponded to approximately eight additional days per year spent in full health.<\/p>\n<p>Self-rated general health scores also improved with semaglutide but worsened with placebo, with a significant treatment difference of +2.15 (p&lt;0.0001), again becoming worse over time with placebo while stable on semaglutide.<\/p>\n<p>Four of the five areas assessed by the questionnaire (mobility, self-care, usual activities, and pain\/discomfort) improved significantly with semaglutide compared with placebo. No significant difference was observed in anxiety\/depression. Benefits were broadly consistent across patient subgroups.<\/p>\n<p>&quot;We were surprised by the extent of the quality-of-life benefits seen with semaglutide, because they were not only clinically meaningful but consistently experienced across multiple aspects of daily life, including physical functioning and overall well-being,&quot; said Professor Johannes Mann, study lead author.<\/p>\n<p>&quot;We were uncertain about quality-of-life outcomes because gastrointestinal side effects are common with GLP-1 receptor agonists,&quot; Prof. Mann furthered. &quot;Our findings confirm that the benefits of semaglutide in chronic kidney disease extend beyond traditional clinical endpoints to subjective outcomes that matter directly to patients.&quot;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>GLASGOW, Scotland, June 4, 2026 \/PRNewswire\/ &#8212; New&nbsp;findings from the landmark FLOW trial, presented at the 63rd ERA Congress, show that once-weekly semaglutide significantly improved health-related quality of life in adults with type 2 diabetes (T2D) and chronic kidney disease (CKD), equivalent to around eight additional days in full health per year. The trial previously [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-44781","post","type-post","status-publish","format-standard","hentry","category-business-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ERA Congress: Semaglutide linked to better quality of life in diabetes and kidney disease, FLOW trial shows - My Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/transmediavictoria.net.au\/?p=44781\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ERA Congress: Semaglutide linked to better quality of life in diabetes and kidney disease, FLOW trial shows - My Blog\" \/>\n<meta property=\"og:description\" content=\"GLASGOW, Scotland, June 4, 2026 \/PRNewswire\/ &#8212; New&nbsp;findings from the landmark FLOW trial, presented at the 63rd ERA Congress, show that once-weekly semaglutide significantly improved health-related quality of life in adults with type 2 diabetes (T2D) and chronic kidney disease (CKD), equivalent to around eight additional days in full health per year. 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