{"id":9404,"date":"2022-05-13T11:09:00","date_gmt":"2022-05-13T11:09:00","guid":{"rendered":"https:\/\/www.prnasia.com\/story\/archive\/3756690_CN56690_0"},"modified":"2022-05-13T11:09:00","modified_gmt":"2022-05-13T11:09:00","slug":"dizal-announces-new-data-from-the-phase-i-ii-study-of-golidocitnib-in-refractory-or-relapsed-peripheral-t-cell-lymphoma-selected-for-oral-presentation-at-2022-eha-annual-meeting","status":"publish","type":"post","link":"https:\/\/transmediavictoria.net.au\/?p=9404","title":{"rendered":"Dizal Announces New Data from the Phase I\/II Study of Golidocitnib in Refractory or Relapsed Peripheral T Cell Lymphoma Selected for Oral Presentation at 2022 EHA Annual Meeting"},"content":{"rendered":"<p><span class=\"legendSpanClass\"><span class=\"xn-location\">SHANGHAI<\/span><\/span>, <span class=\"legendSpanClass\"><span class=\"xn-chron\">May 13, 2022<\/span><\/span> \/PRNewswire\/ &#8212;&nbsp;Dizal<span id=\"spanHghlt048e\"> (SSE: 688192) <\/span>will present the data from an ongoing phase I\/II study of golidocitnib, a selective JAK1 inhibitor, in refractory or relapsed peripheral T cell lymphoma (r\/r PTCL) in oral session at the 27<sup>th<\/sup> European Hematology Association 2022 (EHA2022) Hybrid Congress in <span class=\"xn-location\">Vienna, Austria<\/span>, <span class=\"xn-chron\">12 June 2022<\/span>.<\/p>\n<p>PTCL is a heterogeneous group of clinically aggressive diseases associated with poor outcome. Currently there is no consensus on the standard treatment for r\/r PTCL. Patients with PTCL face an extremely high risk of disease relapse even if they achieved tumor remission following 1L conventional therapy. And the response rates to commonly used 2L agents are below 30%. Hence, there is an urgent unmet need for patients diagnosed with r\/r PTCL.<\/p>\n<p>A couple of years ago, Dizal first identified that JAK\/STAT may mediate the pathogenesis of PTCL and launched clinical studies to test the hypothesis. Golidocitnib is an orally available, potent JAK1 inhibitor with<span id=\"spanHghltfa51\">&nbsp;&gt;<\/span> 200 \u2013 400-fold selectivity over other JAK family members. The agent is currently being studied in the global pivotal clinical trial for the treatment of r\/r PTCL.<\/p>\n<p>Key data (cutoff date: <span class=\"xn-chron\">31 May 2021<\/span>) to be presented at EHA2022 include:<\/p>\n<ul type=\"disc\">\n<li>49 patients completed at least one post-treatment Lugano assessment, of whom 21 have achieved tumor response.<\/li>\n<li>The median duration of treatment (DoR) was not reached, and the longest DoR was &gt;14months.<\/li>\n<li>20 patients (39.2%) experienced grade 3 treatment emergence adverse events (TEAEs) possibly related to the drug. The majority of TEAEs were reversible or clinically manageable with dose modification.<\/li>\n<\/ul>\n<p>The clinical data from the ongoing phase I\/II study of golidocitnib shows good safety and promising anti-tumor efficacy in patients with r\/r PTCL, providing an exciting potential treatment option for these patients. Golidocitnib received FDA Fast Track Designation for the treatment of r\/r PTCL in <span class=\"xn-chron\">February 2022<\/span>.<\/p>\n<p>Earlier results of this study were first presented on <span class=\"xn-chron\">22 June 2021<\/span> during an oral session at the 2021 International Conference on Malignant Lymphoma (ICML) Annual Meeting.<\/p>\n<p>&#8220;We are thrilled to share the updated results from the phase I\/II study of golidocitnib in patients with r\/r PTCL at 2022EHA.&#8221; said Dr. <span class=\"xn-person\">Xiaolin Zhang<\/span>, Chief Executive Officer of Dizal. &#8220;This, along with FDA&#8217;s recent decision to grant Fast Track designation, strengthens our belief that golidocitnib has enormous<span id=\"spanHghlta79d\">&nbsp;potential <\/span>for PTCL patients.&#8221;<\/p>\n<p><b>Details of the oral presentations are as follows:<\/b><\/p>\n<p>Title: A phase I\/II study of golidocitinib, a selective JAK1 inhibitor, in refractory or relapsed peripheral T cell lymphoma<br \/>Session Title: Aggressive Lymphoma \u2013 Novel agents<br \/>Session date and time: <span class=\"xn-chron\">Sunday, June 12<\/span> 11:30 \u2013 12:45 (CEST)<br \/>Session room: Hall C1<br \/>Final Abstract Code: S218<br \/>Presenting Author: Won-Seog Kim, Samsung Medical Center<\/p>\n<p><b>About Dizal <\/b><\/p>\n<p>Dizal is a clinical-stage, biopharmaceutical company, dedicated to discovery and development of differentiated therapeutics for the treatment of cancer and immunological diseases. Deep-rooted in translational science and molecular design, it has established an internationally competitive portfolio of five clinical-stage assets with two leading assets in global pivotal studies.<\/p>\n<p><b>Forward-Looking Statements<\/b><\/p>\n<p>This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words &#8220;anticipate&#8221;, &#8220;believe&#8221;, &#8220;estimate&#8221;, &#8220;expect&#8221;, &#8220;intend&#8221; and similar expressions, as they relate to Dizal, are intended to identify certain of such forward-looking statements. Dizal does not intend to update these forward-looking statements regularly.<\/p>\n<p>These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of Dizal with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond Dizal&#8217;s control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, Dizal&#8217;s competitive environment and political, economic, legal and social conditions.<\/p>\n<p>Dizal, the Directors and the employees of Dizal assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialize or turn out to be incorrect.<\/p>\n<p><b>Contacts<\/b><\/p>\n<p><span id=\"spanHghlt65c2\">Investor Relations: <a href=\"mailto:ir@dizalpharma.com\" rel=\"nofollow\">ir@dizalpharma.com<\/a><br \/>Business Development: <a href=\"mailto:bd@dizalpharma.com\" rel=\"nofollow\">bd@dizalpharma.com<\/a><\/span><\/p>\n<p id=\"PURL\"><img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/c212.net\/c\/img\/favicon.png?sn=CN56690&amp;sd=2022-05-13\"> View original content:<a id=\"PRNURL\" rel=\"nofollow noopener\" href=\"https:\/\/www.prnewswire.com\/news-releases\/dizal-announces-new-data-from-the-phase-iii-study-of-golidocitnib-in-refractory-or-relapsed-peripheral-t-cell-lymphoma-selected-for-oral-presentation-at-2022-eha-annual-meeting-301546912.html\" target=\"_blank\">https:\/\/www.prnewswire.com\/news-releases\/dizal-announces-new-data-from-the-phase-iii-study-of-golidocitnib-in-refractory-or-relapsed-peripheral-t-cell-lymphoma-selected-for-oral-presentation-at-2022-eha-annual-meeting-301546912.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>SHANGHAI, May 13, 2022 \/PRNewswire\/ &#8212;&nbsp;Dizal (SSE: 688192) will present the data from an ongoing phase I\/II study of golidocitnib, a selective JAK1 inhibitor, in refractory or relapsed peripheral T cell lymphoma (r\/r PTCL) in oral session at the 27th European Hematology Association 2022 (EHA2022) Hybrid Congress in Vienna, Austria, 12 June 2022. PTCL is [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":9405,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-9404","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-business-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dizal Announces New Data from the Phase I\/II Study of Golidocitnib in Refractory or Relapsed Peripheral T Cell Lymphoma Selected for Oral Presentation at 2022 EHA Annual Meeting - My Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/transmediavictoria.net.au\/?p=9404\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dizal Announces New Data from the Phase I\/II Study of Golidocitnib in Refractory or Relapsed Peripheral T Cell Lymphoma Selected for Oral Presentation at 2022 EHA Annual Meeting - My Blog\" \/>\n<meta property=\"og:description\" content=\"SHANGHAI, May 13, 2022 \/PRNewswire\/ &#8212;&nbsp;Dizal (SSE: 688192) will present the data from an ongoing phase I\/II study of golidocitnib, a selective JAK1 inhibitor, in refractory or relapsed peripheral T cell lymphoma (r\/r PTCL) in oral session at the 27th European Hematology Association 2022 (EHA2022) Hybrid Congress in Vienna, Austria, 12 June 2022. 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