SAN FRANCISCO and SUZHOU, China, May 16, 2022 /PRNewswire/ — Innovent Biologics, Inc. (“Innovent”) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, autoimmune, metabolic, ophthalmology and other major diseases, today announced that the company will present clinical data from multiple trials in relation to TYVYT® (sintilimab injection), Pemazyre® (pemigatinib), olverembatinib (BCL ABL TIK), IBI110 (anti-LAG-3 monoclonal antibody), IBI376 (PI3Kδ inhibitor), IBI344 (ROS1/NTRK TKI), IBI351 (KRAS G12C inhibitor) and IBI319 (PD-1/CD137 bispecific antibody) at the 2022 American Society of Clinical Oncology (ASCO) annual meeting, June 3-7, 2022. A brief summary of the studies is as follows:
Cancer Type: Gastric cancer
Topic: Efficacy and safety of IBI110 in combination with sintilimab in first-line advanced HER2-negative gastric cancer or gastroesophageal junction cancer: preliminary results from a phase Ib study
Presentation Type: Abstract
Abstract Number: e16097
Researcher: Professor Chenyu Mao, Professor Nong Xu, The First Affiliated Hospital, School of Medicine, Zhejiang University
Cancer Type: Lung cancer
Topic: Efficacy and safety of IBI110 (anti-LAG-3 mAb) in combination with sintilimab (anti-PD-1 mAb) in first-line advanced squamous non-small cell lung cancer (sqNSCLC): initial results from a phase Ib study
Presentation Type: Abstract
Abstract Number: e21145
Researcher: Professor Caicun Zhou, Shanghai Pulmonary Hospital; Professor Nong Xu, The First Affiliated Hospital, School of Medicine, Zhejiang University
Cancer Type: Cholangiocarcinoma
Topic: Pemigatinib in Chinese patients with advanced/metastatic or surgically unresectable cholangiocarcinoma including FGFR2 fusion or rearrangement: updated data from an open-label, single-arm, multi-center Phase II study (CIBI375A201 study)
Presentation Type: Abstract
Abstract Number: e16183
Researcher: Professor Guo-Ming Shi, Professor Jian Zhou, Zhongshan Hospital, Fudan University, Shanghai, China
Cancer Type: Solid Tumors
Topic: IBI110 (anti-LAG-3 mAb) as a single agent or in combination with sintilimab (anti-PD-1 mAb) in patients with advanced solid tumors: updated results from the phase Ia/Ib dose-escalation study
Presentation Type: Poster
Abstract Number: 2650
Researcher: Professor Nong Xu, The First Affiliated Hospital, School of Medicine, Zhejiang University; Professor Caicun Zhou, Shanghai Pulmonary Hospital
Cancer Type: Solid Tumors
Topic: Phase I study of the efficacy and safety of IBI319 (PD-1/CD137 bispecific antibody) in patients with advanced malignant tumors
Presentation Type: Poster
Abstract Number: 2646
Researcher: Professor Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong Provincial People’s Hospital & Guangdong Academy of Medical Sciences
Cancer Type: Solid Tumors
Topic: Phase I dose-escalation study of IBI351 (GFH925) monotherapy in patients with advanced solid tumors
Presentation Type: Poster
Abstract Number: 3110
Researcher: Professor Qing Zhou, Professor Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences
Cancer Type: Hematologic Cancers
Topic: A Phase II, multi-center, single-arm study of parsaclisib, a PI3Kδ inhibitor，in relapsed or refractory follicular lymphoma in China: updated data from the study
Presentation Type: Poster
Abstract Number: 7574
Researcher: Professor Zhong Zheng, Professor Weili Zhao, Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Cancer Type: Lung Cancer
Topic: The Efficacy and Safety of Taletrectinib in TKI-naïve or Crizotinib-pretreated ROS1-positive Non-Small Cell Lung Cancer (NSCLC) Patients.
Presentation Type: Poster
Abstract Number: 8572
Researcher: Professor Wei Li, Professor Caicun Zhou, Shanghai Pulmonary Hospital
Cancer Type: Sarcoma
Topic: Promising antitumor activity of olverembatinib (HQP1351) in patients (pts) with tyrosine kinase inhibitor- (TKI-) resistant succinate dehydrogenase- (SDH-) deficient gastrointestinal stromal tumor (GIST).
Presentation Type: Poster Discussion
Abstract Number: 11513
Researcher: Professor Haibo Qiu, Sun Yat-sen University Cancer Center
About Innovent
Inspired by the spirit of “Start with Integrity, Succeed through Action,” Innovent’s mission is to develop, manufacture and commercialize high-quality biopharmaceutical products that are affordable to ordinary people. Established in 2011, Innovent is committed to developing, manufacturing and commercializing high-quality innovative medicines for the treatment of cancer, autoimmune, metabolic, ophthalmology and other major diseases. On October 31, 2018, Innovent was listed on the Main Board of the Stock Exchange of Hong Kong Limited with the stock code: 01801.HK.
Since its inception, Innovent has developed a fully integrated multi-functional platform which includes R&D, CMC (Chemistry, Manufacturing, and Controls), clinical development and commercialization capabilities. Leveraging the platform, the company has built a robust pipeline of 32 valuable assets in the fields of cancer, autoimmune, metabolic, ophthalmology and other major therapeutic areas, with 7 products approved for marketing in China – TYVYT® (sintilimab injection), BYVASDA® (bevacizumab biosimilar injection), SULINNO® (adalimumab biosimilar injection), HALPRYZA® (rituximab biosimilar injection) , Pemazyre® (pemigatinib oral inhibitor) and olverembatinib (BCR-ABL TKI) and Cyramza® (ramucirumab), 1 asset under NMPA NDA review, 5 assets in Phase 3 or pivotal clinical trials, and an additional 19 molecules in clinical studies.
Innovent has built an international team with advanced talent in high-end biological drug development and commercialization, including many global experts. The company has also entered into strategic collaborations with Eli Lilly and Company, Adimab, Incyte, MD Anderson Cancer Center, Hanmi and other international partners. Innovent strives to work with many collaborators to help advance China’s biopharmaceutical industry, improve drug availability and enhance the quality of the patients’ lives. For more information, please visit: www.innoventbio.com. and www.linkedin.com/company/innovent-biologics/.
Note:
TYVYT® (sintilimab injection) is not an approved product in the United States.
BYVASDA® (bevacizumab biosimilar injection), SULINNO®, and HALPRYZA® (rituximab biosimilar injection) are not approved products in the United States.
TYVYT® (sintilimab injection, Innovent)
BYVASDA® (bevacizumab biosimilar injection, Innovent)
HALPRYZA® (rituximab biosimilar injection, Innovent)
SULINNO® (adalimumab biosimilar injection, Innovent)
Pemazyre® (pemigatinib oral inhibitor, Incyte Corporation). Pemazyre® was discovered by Incyte Corporation and licensed to Innovent for development and commercialization in Mainland China, Hong Kong, Macau and Taiwan.
CYRAMZA® (ramucirumab, Eli Lilly). Cyramza® was discovered by Eli Lilly and licensed to Innovent for commercialization in Mainland China.
Olverembatinib, a novel BCR-ABL TKI in-licensed for co-development and co-commercialization in greater China with Ascentage Pharma.
IBI-376 (parsaclisib) , a potent, highly selective, next-generation investigational novel oral inhibitor of PI3Kδ in-licensed from Incyte for development and commercialization in greater China.
IBI344 (taletrectinib), a novel next-generation ROS1/NTRK TKI in-licensed from AnHeart Therapeutics.
IBI351, a novel, orally active, potent KRAS G12C inhibitor in-licensed from and co-developed with Genfleet.
Forward-Looking Statements
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